In 1980, when Milla was five years old, her family left the Soviet Union for political reasons and emigrated to London. They subsequently immigrated to Sacramento, California, settling in Los Angeles seven months later. In 1987, she began modeling at the age of 12.
She was considered to have a breakthrough with her role in the 1997 French science-fiction film The Fifth Element written and directed by Luc Besson. She and Besson married that year, but soon divorced. She starred as the heroine and martyr in Besson's The Messenger: The Story of Joan of Arc (1999).
In 2002, Jovovich starred in the science fiction horror film Resident Evil, adapted from the video game series of the same name. She reprised her role in four sequels, all in the apocalyptic fiction action horror genre, made between 2004 and 2012.
Jovovich established a charitable foundation in 2005 to help Ukrainian children. At the time she referred to herself: "I am a strong Ukrainian girl, that is why I work a lot".More . . . .